コデインそのものはμ-オピオイド受容体に弱い親和力を示す。主要な鎮痛作用はμ-オピオイド受容体へのモルヒネの親和性による。しかし他の作用または副作用は他のオピオイド受容体への作用による。
Other individuals Have got a genetic distinction that makes them method codeine more rapidly; this can cause increased doses of codeine accumulating faster, and an increased potential for Unwanted side effects.
Gut Blockage. Promethazine/phenylephrine/codeine shouldn't be utilized In case you have a blockage of the intestine (bowel obstruction) or maybe a narrowing on the tummy or intestines. Promethazine/phenylephrine/codeine might make these conditions even worse.
投与方法は経口で、形状は錠、散、シロップがある。錠剤ではコデインはしばしばアセトアミノフェン、アスピリン、イブプロフェンと共に調合される。これらの組み合わせは、それぞれ単体での使用よりも良い疼痛コントロールが可能となる。
Ten with the sixty four instances described the position of cytochrome P450 isoenzyme 2D6 (CYP2D6) genotype. Seven of these sufferers were extremely-swift metabolizers, five of whom died. Ultra-rapid metabolizers of substrates of CYP2D6 transform codeine inside their bodies way too quickly into perhaps dangerously substantial amounts of morphine, the Energetic sort of codeine, contributing to life-threatening or lethal respiratory despair. The 3 other people were being substantial metabolizers, with a person death.
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Utilizing this drugs with any of the next is generally not advised, but could be unavoidable sometimes. If applied jointly, your health practitioner could alter the dose or how often you use this medication, or Present you with Unique Guidance about the use of foodstuff, Liquor, or tobacco.
While you are using this medication, it is particularly significant that the Health care Expert know Should you be taking any of the medicines listed beneath. The next interactions have been picked on The premise of their opportunity significance and they are not automatically all-inclusive.
Mainly because narcotic analgesics could boost biliary tract pressure with resultant boosts in plasma amylase or lipase amounts, determination of those enzyme stages could be unreliable for twenty-four hours following a narcotic analgesic is provided
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Codeine is really a weak narcotic suffering reliever and here cough suppressant that is analogous to morphine and hydrocodone. A little quantity of ingested codeine is converted to morphine in the body.
Allergic reactions to Components. People who are allergic to any of the next shouldn't just take promethazine/phenylephrine/codeine.
The a single scenario where CYP2D6 ultra-speedy metabolizer status was claimed happened in a very five-yr-old child from France who was prescribed only one tramadol dose during the evening publish-adenotonsillectomy and returned on the healthcare facility another early morning with opioid intoxication; he was resuscitated.
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